He published more than papers in the field of ncRNAs in cardiovascular diseases. The journal focuses on fundamental research, translational research, translational science, and clinical research on all topics pertaining to cardiovascular system issues. Based on the findings in murine model of myocardial infarction also larger animal studies are planned to further translate miR therapeutics into the clinics. Details can be found at: The Poster Award of the conference recognizes presenters whose research efforts demonstrate exceptional advances and breakthroughs in the areas of discovery, pre-clinical and clinical aspects of oligonucleotide based therapeutic research.

The funded project investigates the functional relevance of a miR cluster in cardiac ischemia. Clinical data regarding platelet miRNA expression patterns and their interaction with platelet mRNA in diabetes is scarce. Recently, lncRNAs were shown to be additional involved in regulatory processes of cells. Both, miR and its target mimecan were co- expressed in cardiac fibroblasts and smooth muscle cells. Ariana Foinquinos won the 2 nd prize in the Young Investigator Award session for her presentation on the development of a novel treatment for heart failure after myocardial infarction based on AntimiR delivery. This study highlights the potential use of miR as a diagnostic and therapeutic candidate for cardiovascular diseases.

CardioReGenix focuses specifically on overcoming some of the bottlenecks that hamper the development of efficient and safe ncRNA-based therapeutics for vascular regeneration and heart repair by maximizing delivery and expression of ncRNA-based therapeutics in the relevant target cells in the heart.

Our group now identified that the small noncoding RNA microRNA miR is enriched in cardiac endothelial cells and considerably upregulated after cardiac ischemia. SeptemberIm Alter treten eine Vielzahl von Krankheiten auf; insbesondere im Herzkreislaufsystem.

TRAIN Translationsallianz in Niedersachsen is an interdisciplinary network disseration institutes of biomedical research and development aiming to translate therapies and diagnostics from research into clinical application. The findings are published in the journal Circulation Research. State-of-the-art technologies, especially high-throughput methods, as well as an international network are an disseftation basis for the successful development. The new TRAIN Project is specifically focusing on drugs that might limit the pathological heart growth caused by myocardial infarction or high blood pressure.


mhh dissertation 2012

Outstanding Achievement Award to Prof. Professor Thum koordiniert das Vorhaben. April Physiological aging and senescence are associated to progressive decline in most physiological functions, reduced response to stress, loss of viability and increased susceptibility to various diseases. We assessed the diagnostic and prognostic value of all major cardiomyocyte-enriched microRNAs in the context of clinical variables dkssertation a sensitive myonecrosis biomarker in a large ACS cohort.

A link to the journal can be found here: This course, regularly organized by ESACT, brings together scientists and PhD students from academia with lab managers from industry and established research institutes.

Work Group Leaders – REBIRTH Cluster of Excellence

In other parts of her work, she investigated the value of circulating miRNAs as performance biomarkers of marathon runners and the consequence of a single nucleotide polymorphism in the surfactant protein D SP-D gene on microRNA expression dissertahion in the lung. And we can even only dream of a remarkable capacity that newborns have: Urinary miR may thus serve as a novel biomarker of acute kidney rejection.

Read dizsertation about Prof. COST actions do not support individual research projects but rather networking activities, like congresses and exchange of scientists.

mhh dissertation 2012

This study paves a way for future miRNA based therapeutics for treatment of heart failure patients. May We identified miR in the heart to be regulated by osteopontin OPNan important pro-fibrotic cytokine. Publication highlights the protective role of Quaking in preventing doxorubicin-induced cardiotoxicity. Based on the findings in murine model of myocardial infarction also larger animal studies are planned to further translate miR therapeutics into the clinics.


mhh dissertation 2012

February The human genome is like a giant library harboring billions of books, the collective information of life. Arterioscler Thromb Vasc Biol. Altered cardiac autophagy has been reported in various cardiac diseases.

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The intention is to develop drugs which target those RNA regulators in order to modulate the heart function. For more information, please visit www. HiLF II supports more senior scientists who already acquired individual third party funding. August Myocardial infarction leads to cardiac r emodeling and development of heart failure. Recently, lncRNAs were dissertatjon to be additional involved in regulatory processes of cells.

Overexpression of miR or silencing of its targets significantly dissertaton angiogenesis in zebrafish embryos. This success underlines the importance of her research focus regarding the investigation of inhibiting a pro-fibrotic miRNA as a new therapeutic strategy against chronic kidney disease.

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These results suggest an involvement of miR in age-associated cardiac changes, such as cardiac fibrosis. Autophagy is a catabolic process where the cell renews its damaged organelles and non-functional proteins. For the first time the ESC Scientists of Tomorrow and the HFA Heart Failure Specialists of Tomorrow were invited to create each one specific session to increase the visibility also for young active cardiovascular scientists and clinicians.