Management

THESIS ON SCRUB TYPHUS

Though the presence of eschar is helpful in making a diagnostic clue for scrub typhus it is not always present. In developing countries, among the various laboratory tests to diagnose scrub typhus, Weil-Felix test is commonly performed despite its low sensitivity. Diagnosis of scrub typhus. The drawback of serology test is that the advantage of testing directly the presence of organism is not possible [ 14 ]. The most common diagnostic test in India is the Weil-Felix test. Investigation of an outbreak of scrub typhus in the himalayan region of India.

Indian J Med Microbiol. Therefore it is recommended to perform both pathogen and antibody based tests. Articles from Journal of Clinical and Diagnostic Research: This again emphasises the fact that Weil-Felix test is not a sensitive test for diagnosis of scrub typhus. Is scrub typhus a cause of febrile illness among paediatric population of delhi?

Int J Microbiol Res Rev. The IFA slide presents antigens from only 3 serotypes namely Karp, Kato and Gilliam, thus unable to detect other antigenically variable strains of Orientia tsutsugamushi typhks the sensitivity of the test [ 14 ]. An emerging infectious threat.

thesis on scrub typhus

High-level expression of a kilodalton protein gene bor56 of Rickettsia tsutsugamushi Boryong and its application to enzyme-linked immunosorbent assays. Articles from Journal of Clinical and Diagnostic Research: The mite acts as both vector and reservoir of the bacteria and efficiently transmits to thewis off springs through transovarian transmission. An estimated one billion people are at risk for scrub typhus and one million cases occur annually [ 12 ].

  ESSAY STUMBLEINE RHIANNON LYRICS

Serodiagnosis of Scrub Typhus at a Tertiary Care Hospital from Southern India

The most widely performed laboratory test in India is Weil-Felix test which has low sensitivity and specificity. First case of scrub typhus with meningoencephalitis from Kerala: The drawback of serology test is that the advantage of testing directly the presence of scrubb is not possible [ 14 ]. J Clin Diagn Res. The current gold standard for serology is Indirect Immunofluorescence Antibody IFA test which uses a fluorescence labelled anti-human immunoglobulin to detect antibodies in patients serum that have bound to immobilised bacterial antigen that is coated on the IFA slide.

This again emphasises the fact that Weil-Felix test is not a sensitive test for diagnosis of scrub typhus.

The infection is transmitted by bite of larval stage chiggers of mites belonging to the family Trombiculidae. Genome-based construction of the metabolic pathways of Orientia tsutsugamushi and comparative analysis within the Rickettsiales order. Author information Article notes Copyright and License information Disclaimer. Please review our privacy policy. The Immunofluorescence antibody IFA test has its limitations in terms of cost and expertise required.

Serodiagnosis of Scrub Typhus at a Tertiary Care Hospital from Southern India

InKim et al. Support Center Support Center.

thesis on scrub typhus

The test shows false negative results in the early stage of disease as the agglutinating antibodies can be detected only in the second week of illness [ 18 ]. The IgM ELISA with good sensitivity and specificity, ease to perform, swift results and also suitable for testing large number of specimens may be considered as good replacement for Weil-Felix test and IFA test in diagnosis of scrub typhus.

  DISSERTATION ILE DES ESCLAVES DE MARIVAUX

The blood samples were collected from all febrile patients who visited JIPMER hospital during the study periodand were clinically suspected as typhus fever. Scrub typhus is widespread, extending from Japan to Australia and from India to Pacific [ 2 ].

J Assoc Physicians India. Materials and Methods It is a prospective study which was carried out between January to June 3 years 6 monthsin a tertiary care hospital in Puducherry, South India. In developing countries, among the various laboratory tests to diagnose scrub typhus, Weil-Felix test is commonly scrib despite its low sensitivity. Am J Trop Med Hyg.

Expert Rev Anti Infect Ther. This is hospital based study which has its own limitations, therefore future research can be carried out with community-based study to get more data on seroprevalance of scrub typhus in Pondicherry.

Asian J Pharm Clin Res. Find articles by Belgode Narasimha Harish. Typhus fever in Pondicherry. Possibility of scrub typhus in fever of unknown origin FUO cases: The test is widely in use as it is cheap, easily available and does not require technical expertise.