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RENINOMA CASE REPORT AND LITERATURE REVIEW

Reninoma of the left kidney. Constellation of these histological and immunohistochemical features was consistent with the diagnosis of juxtaglomerular cell tumor reninoma. We achieved good blood pressure control with this combination of antihypertensives, and therefore continued with this treatment until the surgical removal of reninoma. Patients with reninoma, however, tend to be older than children with renovascular or renal parenchymal disease, and usually have no or minimal past medical complaints. Metastatic juxtaglomerular cell tumor in a year-old man. Examination of the heart revealed normal heart sounds and no murmurs. Juxtaglomerular cell tumor in an 8-year-old girl.

The production of renin and aldosterone can be influenced by many factors, including the state of hydration, dietary intake of salts, postural changes, and medications The diagnosis of reninoma is usually confirmed by cytoplasmic positivity for renin. Constellation of these histological and immunohistochemical features was consistent with the diagnosis of juxtaglomerular cell tumor reninoma. This case demonstrates the utility of both appropriate imaging studies and selective venous catheterization following provocative administration of an ACE-I for diagnosis. AU – Hofmann, Lawrence V.

Renal vein renin sampling with lateralization might help to identify the site of excessive renin production. Abstract Reninoma is a tumor of the renal juxtaglomerular cell apparatus that causes hypertension and hypokalemia via hypersecretion of renin.

Reninoma: case report and literature review.

Histological examination of the tumor revealed a well-circumscribed lesion measuring 15 mm in diameter with cystic and hemorrhagic changes. Reninoma is a tumor of the renal juxtaglomerular cell apparatus that causes hypertension and hypokalemia via hypersecretion of renin. Cytogenetic examination of the tumor revealed normal female karyotype 46, XX without any renknoma abnormalities. The subject had persistent elevation adn both plasma renin activity PRA and aldosterone. Reninomas are a rare but curable cause of secondary hypertension.

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Reninoma: case report and literature review.

Patients with reninoma usually present with a long history of symptoms suggestive of severe hypertension, such as headaches, malaise, or failure to thrive in younger children. High aldosterone stimulates sodium—potassium exchange by the principal cells of the collecting duct leading to excessive potassium loss in urine, depletion of potassium stores in the body, and stimulation of proton secretion by the intercalated cells of the collecting duct of the kidney 14with the development of hypokalemia and metabolic alkalosis.

Clin Exp Hypertens 15 2: Following partial nephrectomy, the PRA and plasma aldosterone levels declined rapidly and the blood pressure and potassium supplementation requirements normalized.

reninoma case report and literature review

Case report and literature review ‘ Journal of Hypertensionvol. Journal of Hypertension26 2 Pathophysiology of metabolic alkalosis: Diagnostic imaging is employed to identify the source of excessive renin production. Pediatr Pathol 13 4: CTA excluded RAS but lkterature the small subcapsular tumor reninoma of the left kidney as a suspected cause of hypertension.

Leemingsawat C, et al. J Med Assoc Thai.

Am J Med 43 6: On light microscopy, reninomas are composed of closely packed uniform, round to polyhedral cells with granular, eosinophilic cytoplasm. These pathophysiologic changes are not specific for reninoma and are usually present in all renin-mediated causes of hypertension.

Reninoma: Case report and literature review

Following this confirmation, the risks of surgical resection ,iterature be justified. Constellation of these histological and immunohistochemical features was consistent with the diagnosis of juxtaglomerular cell tumor reninoma.

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Ideally, the measurement of plasma and urine electrolytes is done before any treatment including intravenous fluid administration is instituted. Enhanced imaging modalities and invasive renin sampling are helpful diagnostic tests leading to the correct diagnosis. The levels of these hormones can also fluctuate with time, but the elevation above the upper range limit is usually sustained. Our patient presented with long-standing headaches, followed by the development of lethargy, and polyuria with polydipsia.

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Kidney disease is the most common cause of secondary hypertension — one of the reasons why pediatric nephrologists are usually involved in the management of these children. Her other symptoms and signs included a 2-month history of lethargy and intermittent polydipsia and polyuria. Login Register Login using. Patients typically present with a long history of headaches leading to a diagnosis of severe hypertension that responds well to antihypertensive treatment targeting the renin-angiotensin-aldosterone system.

Evaluation of retroperitoneoscopic partial nephrectomy with in situ hypothermic perfusion.

reninoma case report and literature review

Potassium excretion is commonly within normal daily limits; however, this is inappropriately normal excretion, given the depletion of body potassium stores.