Management

RENINOMA CASE REPORT AND LITERATURE REVIEW

Twenty-four-hour urine collection revealed normal sodium mmol and potassium 53 mmol excretion in 1. Kidney disease is the most common cause of secondary hypertension — one of the reasons why pediatric nephrologists are usually involved in the management of these children. Plain radiographs are of limited diagnostic value. Warm ischemic times are usually less than 30 min with no cases of acute kidney injury reported in the literature. Our patient presented with hypokalemia and mild metabolic alkalosis. Link to publication in Scopus. Pubmed Abstract Pubmed Full Text.

Urology 80 1: The tumor cells stain positive for CD A renin-secreting tumour with severe hypertension and cardiovascular disease: The patient was placed in the lateral position with left side up. This case demonstrates the utility of both appropriate imaging studies and selective venous catheterization following provocative administration of an ACE-I for diagnosis.

To confirm excessive production of renin from this tumor, renal vein renin sampling with lateralization was performed. The arrows point to juxtaglomerular cell tumor reninoma.

reninoma case report and literature review

Renal vein renin sampling with lateralization might help to identify the site of excessive renin production. When lirerature to MRI, CT is readily accessed and performed, possesses superior spatial and temporal reninomq, is well tolerated amongst children, and, notably, is the favored modality amongst interventionalists and surgeons when planning procedures.

We describe a case of reninoma and provide a review of the literature, with a discussion emphasizing the diagnostic evaluation for such patients.

They are typically diagnosed in adolescents and young adults with occasional cases reported in younger children 6 — 9. Plain radiographs are of limited diagnostic value.

Other reported symptoms are nausea, polyuria with polydipsia, and fatigue The family history was significant for factor V Leiden deficiency in her father and migraines in her mother and two sisters. The tumor cells were uniform with round nuclei and eosinophilic granular cytoplasm Figure 4 B. Formal renal angiography, though not specifically indicated in cases of reninoma, is often performed in cases of suspected RAS and in cases likely requiring radiological intervention such as balloon angioplasty or pre-operative tumor embolization.

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Surgical resection of reninoma is curative and restores normal blood pressure in the majority of patients.

reninoma case report and literature review

Elevated blood levels of renin and aldosterone confirm the clinical suspicion of renin-mediated hypertension. As an excellent means of imaging of the renal vasculature, renal parenchyma, and adrenal glands, we recommended that CTA be considered in all cases of renin-mediated hypertension in children.

High aldosterone stimulates sodium—potassium exchange by the principal cells of the collecting duct leading to excessive potassium loss in urine, depletion of potassium stores in the body, and stimulation of proton secretion by the intercalated cells literathre the collecting duct of the kidney 14with the development of hypokalemia and metabolic alkalosis. Am J Kidney Dis 58 4: The patient was placed in the lateral position with left side up.

Reninoma: case report and literature review.

Some studies suggest that the possible oncogene s or tumor suppressor gene s may be localized on chromosome 4 and 10, or chromosome 9 and 11, respectively 325 J Clin Hypertens Greenwich 14 A urine electrolyte excretion study confirmed inappropriately normal potassium excretion contrary to what we would expect given the low blood level of potassiumsuggestive of hyperaldosteronism. Reninomas are a rare but curable cause of secondary hypertension.

There was no organomegaly or masses palpable in the abdomen. Reninomas are usually small subcapsular tumors, well circumscribed, and mostly encapsulated.

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reninoma case report and literature review

Evaluation of retroperitoneoscopic partial nephrectomy with anf situ hypothermic perfusion. These pathophysiologic changes are not specific for reninoma and are usually present in all renin-mediated causes of hypertension.

Both, the degree of hypokalemia and the amount of potassium excreted in urine, are influenced by the dietary intake of potassium.

Reninoma: case report and literature review.

Increased production of renin from the affected kidneys causes blood pressure elevation, leading to the development of renin-mediated hypertension. Diagn Pathol 6: J Urol 6: Warm ischemic time of the procedure was 18 min. J Med Erport Thai. Our patient presented with long-standing headaches, followed by the development of lethargy, and polyuria with polydipsia.

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In designing the optimal approach for our patient and her renin-secreting tumor, we appreciated the likely benign nature of this lesion We will be provided with an authorization token please note: A laparoscopic transperitoneal approach, with mobilization and reflection of the splenic flexure, allowed exposure of the anterior surface of the left kidney.

Although both retroperitoneal and transperitoneal minimal access routes have been described 2223we adopted rfview transperitoneal route in our patient because of a large experience with transperitoneal partial nephrectomy for adult renal tumors in our department.

No chromosomal abnormalities were detected in our patient.