Mucoid and whirling after cutting. The tumor was completely excised with free margins. There are occasional nucleoli and very little mitosis occurs. These cases are very common, and often unexpected. USG reveals hypoechoic cystic mass and usually remains insufficient for diagnosis. Although this finding initially suggested the use of the HMGA2 gene as a marker for this malignancy, the idea was rejected because the translocation is often shared by other mesenchymal tumors such as uterine leiomyomas, lipomas, pulmonary hamartomas, liposarcomas, and hemangiopericytomas. To date few cases have been described in sites other than these areas 2, 4, 7,

Management requires complete removal of the lesion and the clinical and imaging follow-up given their high rate of recurrence. Its size varies from 1 cm to 60 cm, but is commonly larger than 10 cm. Mucoid and whirling after cutting Microscopy: No gastrointestinal symptoms were determined. There are occasional nucleoli and very little mitosis occurs.

This suggests that clinical follow-up should be done for all cases 1, 2, 4, 7, About 2 years later Begin published his experience with 9 patients which included the first report of this entity among men 5.

aggressive angiomyxoma a case series and literature review

Histopathologic examination cae an AA. View at Google Scholar J. Chemotherapy antiomyxoma no beneficial results for adjuvant therapy because of low mitotic activity of the tumor. At the periphery of the lesion, the vessels were thicker due to perivascular hyalinization and medial hypertrophy. Monitoring includes periodic MRI imaging which has ruled out tumor recurrence to date. Aggressive angiomyxoma AA is a rare pelvic soft-tissue tumor often found in the perineum which originates from myocardial fibroblasts.

An immobile, painless mass which filled lower quadrants of the abdomen was palpated.


Aggressive angiomyxoma: a case series and literature review.

According to the immunohistochemical findings of the present tumor, our case was diagnosed as AA. In view of these findings, we think that there is still a lack of knowledge about the diagnosis of AA among the clinicians.

However, it may be detected even after postoperative 15 years [ 11 ]. Exploratory laparotomy was planned. Because of this clinical manifestation, AA is often initially misdiagnosed as a gynecological malignancy or a groin hernia that leads to unnecessary surgical interventions [ 78 ].

Whether or androgen agonists should be used to treat male patients who test positive for androgen receptors has not yet been determined 2.

Aggressive angiomyxoma: a case series and literature review.

There is only one study evaluating the pathogenesis of AA in the current qngiomyxoma in which Nucci and Fletcher [ 15 ] suggested a translocation at the level of chromosome 12 where the high mobility group protein HMGA2 a transcription factor expressed during embryogenesis is located.

Until we have more information these chromosomal findings are not uniform in any way, but rather mere curiosities10, 11, 14, AA is a locally infiltrative slow growing tumor with esries marked tendency to local recurrence. Since AA was first described in by Steeper and Rosai [ 10 ], approximately cases have been reported in medical literature up to date.

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Case Reports in Surgery

Abstract Aggressive angiomyxoma AA is an uncommon mesenchymal tumor that is mostly derived from the female pelvic and perineal regions. It reduces high levels of circulating estrogen and prevents conversion of endogenous estrogen and adn achieved tumor volume reduction from transverse measurements of 8. Macroscopically, tumors are usually firm or gelatinous with diameters of 10 cm or more.


On exploration, a giant, soft, rubbery, and gelatinous appearing mass like lung tissue that approximately filled the whole abdomen was noted. Lesions disappear or their size, as measured clinically and with imaging, decreases within three litetature to a year.

Aggressive Angiomyxoma of the Male Genital Region.

Archive ouverte HAL – Aggressive angiomyxoma: A case series and literature review

In general, these lesions occur in the pelvis, perineum and inguinal region Nevertheless, it has been suggested that it can be used for evaluation of margins and in the detection of small foci of residual tumor excisions or recurrences.

All adjuvant treatment modalities remain controversial [ 8 ].

aggressive angiomyxoma a case series and literature review

Literxture, the highest recurrence rates after resection still remain a major surgical problem that should be solved. AA should be distinguished literxture other relatively more common encountered benign or malign soft-tissue sarcomas of the abdomen such as myxoma, fibrous histiocytoma, angiofibroma, liposarcoma, nerve sheath tumor, mixed mesodermal tumor, and angiomyofibroblastoma AMF [ 12 ].

It is locally aggressive and metastasizes quickly and easily. USG reveals hypoechoic cystic mass and usually remains insufficient for diagnosis. The Journal of Urology ; Report of a Case and Review of the Literature. Nevertheless, angiomyxoma, unlike angiomyofibroblastoma, tests positive for factor VIII and negative for smooth muscle actin 3, 4, 7.

aggressive angiomyxoma a case series and literature review